MeRG® containing type I native collagen, stimulates platelet aggregation, by interacting with the membrane integrins and thereby prompting quicker coagulation.
MeRG® acts directly over the stages of the histological repair process:
• fibroblast proliferation
• new tissue formation
By acting as close-knit three-dimensional scaffold, it traps and holds mesenchymal stem cells (M.S.C.) and blood, including platelets, which release PDGF (Platelet Derived Growth Factor)
MeRG® made of type I collagen, and interacting with the fibroblast receptors, chondroblasts involved in the synthesis of connective and cartilage tissue structures, becomes an ideal substrate for histological repair.cells adhere to the superficial heterologous collagen fibres, proliferate and orientate in order to reshape the damaged tissue. The presence of the collagen membrane in the treated area therefore supports the new autologous tissue formation, thereby encouraging efficient regeneration.
This is the basic substance of the extra-cellular matrix. There are at least 19 types of collagen, all with different structural and physical-chemical characteristics. The pure, non-denatured type I collagen retains the typical triple helix structure typical of all species of the animal world, and is recognised as belonging to the human organism. Collagen originating from equine Achilles’ tendon is pure, and is today the preferred choice as equines have the added advantage of being free from the risk of B.S.E.. Type I collagen has a dual action mechanism, being both biologically active and plastic, thereby allowing for the protection of the lesion, maintaining an ideal environment and enabling the most important biological processes of tissue repair, stimulating new tissue formation.
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